Heart Failure: A Comprehensive Guide to Diagnosis and Treatment

HEART FAILURE: A Comprehensive Guide to Diagnosis and Treatment / Editor G. William Dec

Heart failure is a growing world-wide epidemic with a prevalence of more than 5 million cases in the United States and 6.5 million cases in Europe. Epidemiologic data demonstrate a rapid increase in its incidence during the past two decades.

This trend is likely to continue as the population ages. It is currently the most common hospital discharge diagnosis for patients over the age of 65 years and accounts for substantial morbidity and high mortality.

Fortunately, major advances have occurred in our understanding of the cellular mechanisms, pathophysiological abnormalities, nonpharmacologic therapy and surgical therapeutic options for this syndrome during the past decade.

This textbook focuses the most recent developments in the pathogenesis, etiologic considerations, diagnosis, and treatment of heart failure and has been written by internationally recognized physicians and scientists involved on a daily basis in heart failure research and clinical care.

The authors’ aim is to provide an up-to-date and comprehensive review of the diagnosis and treatment of heart failure. The text is divided into five sections that concisely summarize fundamental cellular and molecular bases for heart failure, its pathophysiology, current invasive and noninvasive diagnostic techniques, pharmacologic advances and de-vice-based therapy, surgical options, and evolving molecular therapies.

The first section focuses on the tremendous advances that have occurred over the last decade in our understanding of the basic mechanisms of heart failure. These discoveries have reshaped our understanding of the basic causes of “the heart failure phenotype” and will allow us to redesign therapeutic strategies for the treatment of this disease.

These chapters specifically focus on the genetics of dilated and hypertrophic cardiomyopathy, the role of hypertrophy and apoptosis, beta-adrenergic receptor signaling, and excitation-contraction coupling abnormalities that contribute to ventricular dysfunction.

In each of these chapters, the role of new tools, such as microarray analysis, proteomics, and molecular imaging are detailed.

CONTENTS:

Part I Cellular and Molecular Basis for Heart Failure

  •  The Genetics of Dilated and Hypertrophic Cardiomyopathies
  •  Molecular Signaling Networks Underlying Cardiac Hypertrophy and Failure
  • Mechanisms of Cell Death in Heart Failure
  • Excitation-Contraction Coupling Mechanisms in Heart Failure
  •  B-Adrenergic Signaling in Heart Failure

Part II Pathophysiology of Heart Failure

  •  Ventricular Remodeling and Secondary Valvular Dysfunction in Heart Failure Progression
  •  Neurohormonal and Cytokine Activation in Heart Failure
  • Cardiomyopathies in the Adult (Dilated, Hypertrophic, and Restrictive)
  •  Heart Failure with Normal Systolic Function

Part III Clinical Heart Failure: Diagnosis and Treatment

  •  The Clinical Syndrome of Heart Failure
  •  Clinical Profiles and Prognosis in Heart Failure
  •  Conventional Therapy of Chronic Heart Failure: Diuretics, Angiotensin-Converting Enzyme Inhibitors, and Digoxin
  • Conventional Therapy of Chronic Heart Failure: Beta-Adrenergic Blockers
  •  Angiotensin Receptor Blockers for Heart Failure
  •  Role of Mineralocorticoid Antagonists in Patients with Heart Failure
  •  New Pharmacologic Therapies in Heart Failure: Immunotherapy, Kndothelin-1
  • Antagonists, Brain Natriuretic Peptides, and Neurohormonal Interventions
  • Role of Mineralocorticoid Antagonists in Patients with Heart Failure
  • New Pharmacologic Therapies in Heart Failure: Immunotherapy, Hndothelin-1
  • Antagonists, Brain Natriuretic Peptides, and Neurohormonal Interventions
  • Treatment of Diastolic Heart Failure
  • Cardiac Resynchronization Therapy
  • Management of Atrial and Ventricular Arrhythmias in Heart Failure
  • Heart Failure in Special Populations
  • Practice Guidelines for Heart Failure Management

Part IV Surgical Options for Heart Failure

  • Coronary Revascularization, Mitral Valve Repair, Left Ventricular Remodeling, Procedures and Devices
  •  Long Term Mechanical Circulatory Support and Cardiac Transplantatio

Part V Molecular Therapies

  •  Targeted Gene Transfer in Heart Failure
  •  Cellular Transplantation

Language: English
Format: PDF
Pages: 602
Size: 6 mb

Password: bookboxpdf.com
Free download HEART FAILURE: A Comprehensive Guide to Diagnosis and Treatment
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